summer safety tip #1

it's sweltering today.

i mean, hot and humid. the reason i can never live in the south.

i tried to run early this morning to avoid the humidity, but it was already almost unbearable. the only place with a breeze was by the river. seems like people might be tempted to go swimming today. in fact, i'm sure that a lot of folks will. i only hope they adhere to this very important summer safety tip:

DON'T SWIM IN FECULENT POOLS!

i am on PICU night float this month. already, we have had two cases of hemolytic uremic syndrome, or HUS, one of which was likely caused by a child swimming in a water source contaminated by Escherichia coli 0157:H7.
HUS is a syndrome that is typically characterized by a prodrome of diarrhea (90%) or an upper respiratory tract infection (the other 10%). the classic triad of HUS is hemolytic anemia, thrombocytopenia and acute renal failure. it usually occurs in kids <4 style="font-style: italic;">Yersinia, Salmonella, and Campylobacter species, Streptococcus pneumoniae and Clostridium difficile. 70% of HUS cases in children result from E. coli 0157:H7 or Shigella dysenteriae, both of which produce a toxin (shiga- or vero-toxin) that damages the lining of the blood vessels, or endothelium, throughout the body.

the effect of this toxin-mediated damage is profound. fibrin and platelets adhere to the damage on the vessel walls, resulting in low platelets (thrombocytopenia) and tiny little clots called microthrombi. red blood cells are either damaged by the toxin or chewed up as they try to flow past these thrombi (a process called microangiopathic hemolytic anemia).

(normal red blood cells above, damaged red cells below, called schistocytes.)

in HUS, these microthrombi occur primarily in the kidney, resulting in kidney failure. but, really, any organ can be involved. the picture below is of a portion of a kidney called the glomerulus, which is really just a tuft of small blood vessels. the light pink smudgy stuff at the end of the arrow is a microthrombus.

in a similar disease process seen more commonly in adults, thrombocytopenic thrombotic purpura (TTP), microthrombi occur in the brain, spleen, liver, pancreas, heart and kidney. TTP has a much poorer prognosis.

both kids in question had had several days of bloody diarrhea. we're not talking a few streaks here and there that you could explain with a fissure or hemorrhoid. we're talking lots of blood. both were dehydrated, anemic and thrombocytopenic. both had stool cultures that were positive for E. coli 0157:H7. both were in renal failure and are now at TBFCHITW (that's for you, flea, if you are reading this) on dialysis.

one of the most important questions from a public health standpoint is how did they get it? E. coli live among us. most are not harmful and are considered normal flora in our intestines. you might hear them referred to as coliform bacteria. we actually need these commensal organisms to digest our food. They actually make vitamin B12, amongst others, that we need to live. the 0157:H7 serotype is not so friendly or helpful.

0157:H7 is in contaminated meat, such as hamburger. if this doesn't make you want to be a vegetarian, nothing will. you are actually more likely to get 0157:H7 from hamburger than from a steak, as the bacteria are on the surface of the steak (and, hence, are killed in the cooking process) but get mixed up when the beef is ground up to make hamburger. raw or undercooked hamburger is often the culprit with outbreaks of 0157:H7.

another potential source is inadequately washed or unwashed produce. remember the spinach that was the source of the outbreak last fall? it's called fecal-oral contamination. enough said.

0157:H7 also lives in and on cows and other farm animals. some outbreaks have been tied to petting zoos.

contaminated water supplies are another concern, particularly in rural areas where there are a lot of cattle. pay attention to the coliform counts! this tells you how much poop has been in the water. the fish and wildlife service checks water supplies for coliform counts regularly and will close a pond or lake if the level is high enough.

the moral of this cautionary tale is to:
1) avoid contaminated water supplies (aka, the feculent pool)
2) take your child to the doctor when they have bloody diarrhea (please do this if nothing else!)
3) avoid raw/undercooked beef, unwashed vegetables/fruits, and unpasteurized milk or fruit juices

when it comes to E. coli 0157:H7, an ounce of prevention is worth everything.

ondine's curse

he lay quietly, the rhythmic breaths from the vent lulling him deeper into sleep. his mother, weary from lack of sleep, sat in a chair at the bedside, unwilling to leave him. if he woke, he would want her.
before this night, i did not know the extent of their journey together, this young boy and his mother. as it became clear that he would sleep soundly, the tension drained from her face. i asked her how it all began. as she eagerly began to recount their story, i was struck by how young she looked, after having been through so much.
there were multiple, frustrating trips to emergency rooms, doctors who told her that there was nothing wrong. once it became clear to all who knew him that there was, indeed, something wrong, an excruciatingly long stay in the PICU. yet, still, no diagnosis.
finally, after much searching and many tests, the diagnosis was clear. ondine's curse. congenital central hypoventilation sydrome (CCHS), a rare disorder that causes sleep apnea and usually requires tracheostomy and life-long mechanical ventilation, but only at night.

the name of the disorder, ondine's curse, comes from the myth of ondine. in the current rendition of the story, ondine was a water nymph, stunningly beautiful, who fell in love with a human. when she married him and bore his child, she lost her immortality. as she aged, her husband lost interest in her and was unfaithful to her. she discovered him in the arms of another woman and cursed him, telling him that as long as he remained awake, he would live, but as soon as he slept, his breath would desert him.

in the original tale, "Undine" by Friedrich de la Motte, undine's father, a prince of the mediterranean sea, wishes for her to possess a soul, as undines' do not have souls. (undines are spirits of the elements, earth, water, wind, fire.) he sends her to live with a fisherman and his wife who have lost their own daughter, bertalda, after she wandered away (lured by undine's uncle, kuhleborn).

when undine is 18, a knight, huldbrand von ringstetten, comes to the fisherman's cottage and falls in love with her. only once they are married does she tell him of her heritage. she tells him that if he is to reject her, to do it then and she will return to the crystal palaces of her father, "a soul-endowed woman". huldbrand does not reject her, but vows his never-ending love for her and takes her to live with him in his castle near the danube.

bertalda, who finally discovers her true identity, lives with undine and huldbrand. undine's water-spirit uncle, kuhleborn, will not let them live in peace. he haunts them by emerging from the fountain of the castle and taking human form. to prevent him from doing so, undine places an enchanted stone over the fountain to keep kuhleborn away. they live peacefully for a time.

however, when the three of them attempt to travel to vienna, bertalda drops her necklace, given to her by huldbrand, into the water. undine summons a beautiful red coral necklace out of the watery depths. huldbrand is enraged by this, realizing that his beloved wife is still connected to her water-spirit family. despite undine's warning that should he ever be angry with her that her family will recall her to her watery home, huldbrand expresses his anger and undine is taken back beneath the water where she lives in sorrow. as long as huldbrand is faithful to her, he can continue to draw breath. if he is not, he will die.

at first, huldbrand is grief-stricken and weeps and weeps for his beautiful undine. however, his grief for his wife fades and he eventually plans to wed bertalda, even though his love for undine remains true. bertalda agrees to marry him even though she knows he is still in love with undine. the night before their wedding, bertalda foolishly removes the stone from the fountain, allowing undine to rise from the water to fulfill her curse:

There was a gentle tap at his door. Undine used to tap thus when she wanted playfully to tease him "It is all fancy," said he to himself; "I must seek my
nuptial bed."

"So you must, but it must be a cold one!" he heard a tearful voice say from without, and then he saw in the mirror his door opening slowly--slowly--and the white figure entered, carefully closing it behind her. "They have opened the spring," said she softly, "and now I am here, and you must die."

He felt in his paralyzed heart that it could not be otherwise, but covering his eyes with his hands he said: "Do not make me mad with terror in my hour of death. If you wear a hideous face behind that veil, do not raise it, but take my life, and let me see you not."

"Alas!" replied the figure, "will you then not look upon me once more? I am as fair as when you wooed me on the promontory."

"Oh, if it were so!" sighed Huldbrand, "and if I might die in your fond embrace!"

"Most gladly, my loved one," said she; and throwing her veil back, her lovely face smiled forth divinely beautiful. Trembling with love and with the approach of death, she kissed him with a holy kiss; but not relaxing her hold she pressed him fervently to her, and as if she would weep away her soul. Tears rushed into the knight's eyes, and seemed to surge through his heaving breast, till at length his breathing ceased, and he fell softly back from the beautiful arms of Undine, upon the pillows of his couch--a corpse.

the story has been immortalized in many different forms, ballet, theater, animation (disney's "the little mermaid" is a veiled re-telling of the myth), painting and sculpture (the above painting, "Ondine", is by Paul Gaughin). time has changed the essence of the story, which, it turns out, is quite beautiful and tragic.

the boy slept soundly all night. after telling me their story, his mother slept soundly, as well. the reason they are in the PICU? he had phrenic nerve pacemakers placed. once they are turned on next month, controlled by a remote control box, the pacemakers will stimulate his phrenic nerves, which stimulate his diaphragm to move and, thus, to breathe. eventually, we will be able to remove his trach and he will be able to talk and laugh and breathe, even as he sleeps. amazing.

terrapin station

i was driving home tonight after a surprise farewell dinner party organized by a 5yo CF patient for her beloved pulmonologist (and my incredibly wonderful mentor). it was a fun evening, full of stories, laughter, and the entertaining antics of the 5yo and her little brother, almost 2yo.
as i walked to my car, feeling a little bittersweet, i looked up and saw a thin sliver of a crescent moon and venus, nestled in the moon's curve. it reminded me of an old, favorite grateful dead song.

"Counting stars by candlelight, all are dim but one is bright;
The spiral light of Venus, rising first and shining best,
All along the northwest corner, of a brand new crescent moon,
While crickets and cicadas sing, a rare and different tune,
Terrapin station."

i can't quite explain why, but it was one of those moments when you just have to pause and wonder at the beauty of everything.

a rhetorical question

why is it that men are never more interested than when a woman seems disinterested or, at the most, ambivalent?
i got called down the the ED last night for some emergent ear pain at 3:30am. turned out to be a ruptured ear drum, quite painful but also not quite an emergency. while i was down seeing this child, i ran into another resident with whom i used to hang out. we may have had a few dates last fall. he seemed interested at first, but then not so much, so we just drifted. i hadn't seen him in quite some time until last night. suffice to say, he seemed interested again. what is it about guys? why can't they make up their minds?

a running interlude

i went for my long run today. yup. i'm training again for the half-marathon in august to raise money for our hospital.
i went on a new route today, courtesy of one of the picu nurses who lives in my neighborhood and runs it all the time. it's was great. it takes you out on back roads in vermont that ever so gently roll. there are a few hard hills, but they fortuitously hit just as the nirvana section of my running mix kicked in. plus, the view at the top is stunning. there's not too much traffic, only when it loops back around to cross over the bridge into new hampshire. but that section is pretty short and there's a sidewalk.
i was post-post-call today, which is actually the worst day in terms of fatigue after being up all night. but i pushed through the haze and protest from my quads and persevered.
this year, my goal is to raise more money ($1006 last year) and finish faster. last year was all about proving to myself that i could actually do it. this year is about doing it with style and much, much more grace. given that i actually have time to train, it just might happen.

cross-cover

so i've got a lot of cross-cover in the picu this month.

cross-cover is when you are on-call at night for a service that you are not rotating on that month. in the picu, this can be a bit dicey, as the kids can be quite sick (obviously) and you don't really know them. we have a 10-bed picu. compared to some hospitals, that's pretty small. so, you think, how bad could it really be, right? well, it can be bad. especially as our attendings are not in-house and you are basically on your own. Thank god for picu nurses.

i blogged about my first cross-cover this month in a recent post.

last night wasn't as bad, but it still freaked me out and i didn't leave the unit.

i managed 9 kids, 4 of whom are on vents, 1 of whom was the first kid i'd ever managed with DKA, or diabetic ketoacidosis.

DKA is how many children present when they are first diagnosed with type I diabetes, which is the type associated with autoimmune destruction of the pancreas and, thus, endogenous insulin production.
Normally, when you eat food, your body breaks it down into smaller parts, including glucose from carbohydrates. When glucose levels in your blood rise, this triggers your pancreatic cells (see diagram below) that make insulin (the islets of Langerhans) to secrete insulin. your liver, fat and muscle cells need insulin in order to use glucose for energy.

In type I diabetes, the islets of Langerhans have been destroyed by autoantibodies. So you can't release insulin in response to elevated blood glucose levels.
when glucose builds up in your bloodstream, that's bad. in order to keep your brain going, your body starts to use fat to make energy, resulting in the formation of ketone bodies (the keto- in ketoacidosis). these use up your buffers, resulting in acidosis. the elevated blood glucose results in an osmotic diuresis. a typical patient with DKA is about 7-10% dehydrated as a result. dehydrated and essentially starving. this kid had lost 15lbs in 3 weeks.

in a purely abstract way, it's sort of fun to manage these patients. i'm an orderly person. i like things that are predictable, things that make sense. when you are reversing the acidosis of a kid with DKA, it's orderly, predictable. the glucose falls, the pH corrects, the sodium rises, the potassium falls. usually the phosphate falls, too. you can anticipate all these things, plan for them. hourly labs. data sheets to track your progress.

in a not so abstract way, it's not so fun to manage these kids. they're scared. sometimes they are super sick. they are getting poked hourly for blood. their life is changing and they feel completely out of control. from a doctor's perspective, you are scared to death that they will get one of the dreaded complications of DKA, cerebral edema, so you're constantly checking their mental status to make sure they are not deteriorating. i kept asking this kid's nurse to wake her up and see if she had to pee. she didn't. and i think i just ended up annoying my nurse. good thing he likes me and just thinks i'm funny when i get all paranoid.

this kid did really well. no cerebral edema. by 4am, her glucose was normal again, her serum ketones were almost cleared. she didn't have horrible sodium or potassium derangements. her acidosis had corrected.

all was well in terms of her physiologic state.

she has a long road ahead of her, but she strikes me as one of those mature-for-her-age kids who will do just fine.

knocked up

for those who need a good laugh, go see the new jeff apatow movie, knocked up. it's fairly clear that the script was written by a man, but it's worth seeing anyway. i laughed. and i desperately needed a good laugh.

the myth of sisyphus

post call today after a long, sleepless night in the PICU. i have this vague recollection of leaving the bedside at one point to brush my teeth, but otherwise, not at all.

i am left with a sense of defeat, as if i have been foolishly trying to hold water in a sieve. no matter how much water i put in, it all just flows out again, mocking my efforts and highlighting my naive, all-too-tentative confidence that i know what i am doing.

as the sun began to appear on the horizon, the nurses and i took a moment to breathe and enjoy the beauty. she was momentarily improving, but my intuition was that this, too, would pass.

these are the patients that leave you wondering why it is that we do what we do, when it just seems futile? as if god, if you believe in such an entity, just has a different plan? you struggle to eek out some small iota of change. but in the end, the DIC, ARDS, and sepsis win, just as sisyphus' rock inevitably rolls back down the hill. yet, he rolls it back up again.

i have blogged in the past about other chronically ill children who have passed away, some with more peaceful deaths than others. as a general rule, i support a family's desire to do everything possible. so what do you do in cases where respecting the family's wishes feels unethical? when it feels like every intervention is painful and only serves to prolong the patient's suffering?

when i came home this morning, the sun was shining. spring is in full force here and it is breathtaking. i fell asleep and did not dream. i awoke this afternoon to lightning, thunder and the sound of sheets of rain falling on my metal roof. as i sit here typing, the rain has passed, the storm clouds are receding to the east, the sun is peeking through the clouds again over the greens. mother nature as metaphor.

what are the chances?

i drove home from smallish state to even smaller state last night through the most amazing lightning storm. it got me thinking. what is it about a car that makes it a safe place to be? what are the chances that you'll get struck by lightning? are you more likely to get struck by lightning or to get swept away by an avalanche? well, i suppose the latter would depend on whether you lived in a place where avalanches occur.
at any rate, i googled lightning strikes this morning and found all the answers to my questions and then some.
-you have a 1:5000 chance of getting struck by lightning during your lifetime
-9 out of 10 people survive a lightning strike
-a lightning bolt strikes the earth a hundred times a second, heating the air around it 5 times hotter than the surface of the sun
-lightning strikes kill more people each year than tornadoes or hurricanes (about 2000 people worldwide each year versus 150 people killed by avalanches each year)
-cars are safe not because they aren't struck but because the tires conduct the charge to the ground
-lightning bolts start as negatively charged particles that extend towards the earth and are met by positively charged particles called streamers extending up from the earth; when the two oppositely charged particles meet, an electric current is formed that makes the flash (for a really neat demo, check out this national geographic interactive site (yes, i am aware that i am a geek).


some safety tips from national geographic (what can i say, i'm a pediatrician ;):

• If outside, seek refuge in a car or grounded building when lightning or thunder begins.
• If inside, avoid taking baths, or showers, and washing dishes. Also avoid using landline phones, televisions, and other appliances that conduct electricity.
• Stay inside for 30 minutes after you last see lightning or hear thunder. People have been struck by lightning from storms centered as far as 10 miles (16 kilometers) away.
• If caught outside away from a building or car, stay clear of water bodies and tall objects like trees. Find a low spot or depression and crouch down as low as possible—but don’t lie down on the ground. Lightning can move in and along the ground surface, and many victims are struck not by bolts but by this current.

google is a miracle (edited post reflecting flea debacle)

seriously.
how did we manage before google existed? how did we ever find images to put in our power point presentations? how much more tedious was it to find scientific articles when we had only pub med? how else do you find out if the guy you met in that random NYC bar who said he was an "architect" is, in fact, an architect and not an ax murderer?
i challenge any and all readers to honestly say that google has not changed their lives in some meaningful way. how you define meaningful is, of course, up to you.

addendum:
i published this post this morning, before i realized the maelstrom of scandal going around the blogosphere regarding my friend flea. (hey, i've been on vacation in a place with no internet. yes, places like that do still exist. you just have to drive really far to get there.)

if you have no idea what i'm talking about, check out this post by Adventures of an Awesome (Sometimes) Mother. it has links to both the globe article and the blogosphere response, from both the medical and legal side.

i'm also intrigued by kevin MD's post on your google reputation.

there are many opinions floating around out there about what happened. i'll refrain from giving mine, as i'm not sure more needs to be said. all i will say is that medical blogs are forever changed, for better or worse. flea has left his indelible mark, as he always did and hopefully will do again.

I may have had my head under a vent for the last month but c'mon...

In news that can only go under the category of why do we care , I give you this link from the BBC. No wonder we are so despised around the world.

In other news for those with more on their minds than the fate of over-privileged heiresses who are going to jail for crimes they obviously committed, here is a story worth reading. Contrary to all the anticipatory guidance that pediatricians have been giving parents for years about juice, the abstract, which analyzed data from the NHANES study, basically says that 100% fruit juice won't make kids obese. This is only an abstract, the article points out, and needs to be further scrutinized in a peer-reviewed journal. However, the message is truly revolutionary.

Think I'll go have an Odwalla Superfood to celebrate the occasion.

MIA

So things got a little busy, as evidenced by my lack of posts. April was consumed in a whirlwind of micro-preemies on oscillating ventilators, many sleepless nights filled with record-breaking numbers of blood gases and an overall feeling of exhaustion. I started the month with 3 really sick babies, two of whom were on an oscillator and had profound nosocomial sepsis. By the end of the month, all 3 are off the vent and have "graduated" to the less-acute side of the nursery where they enjoy kangaroo care, isolettes instead of open-bed warmers and are working on their feeds. Now that is what I call a satisfying month.
After a week on community practice, the exhaustion is fading, although I am now plagued with a viral illness that decided now was the opportune time to strike. I guess I have to agree with the timing, as it really wasn't an option to get sick in the NICU.
It's spring here, finally. Trees are blooming. Daffodils are coming up. I no longer cough when I run outside. Life is good, or at least better.

you know you work too much when...

...you and 2 other peds residents can think of nothing more scintillating on a Friday night than wandering through the aisles of CVS comparing ingredients in children's cold and flu remedies.

long lost friend

I found an old friend today. We went to med school together. He graduated a year ahead of me and went into the Marines. We sort of lost touch for a while. Last week, I sent an email into the void, just to see how things were. His reply came this morning to my inbox, "unclassified" status. Turns out, he just left for Iraq. Before he left, though, he started a blog, Another Doc in the Sandbox. Check it out and wish him safe journeys.

U2

On the way to work this morning, I heard three songs on the radio. I tend to flip stations frequently, so they were all on different stations. But all three songs were by U2. What are the odds?

don't get sick in july

There's a piece in the NY Times Week In Review that details the worst days to do certain things. To sum up:

• Don't have a heart attack on a weekend, as you are more likely to die from lack of aggressive treatment.
• Don't go to the theater on a Saturday night, as you are likely to be surrounded by snoring, drunken couples who wanted to have a night away from the kids.
• Don't go to a nice restaurant on Monday, as you are likely to be served left-over fish by second-string staff.
• Don't have a baby on a weekend unless you can help it, as the hospital is more likely to be under-staffed and your baby is more likely to die (the author's contention, not one that I agree with).
• Don't send email on Sundays or late at night; apparently spam goes out between 2-5 am and your email will be mixed in with offers for cheap Viagra or notices that somehow they lost your personal identifying information on that order you never placed (under the rock they think you were born under) and would you please re-send your SSN and bank routing number?
• Don't buy a car on a weekend day in the fall (try weekday in July or August).
• Don't fly in the late afternoon (or anytime in December if you can help it). Duh.
• Don't get arrested on a weekend, as you will likely find yourself in a holding cell until the judge gets back from his golf game or hunting trip.

I would add the following:

• Don't get really sick in July unless you want an intern taking care of you who has no idea what they are doing.
• Don't make appointments in clinic for late in the afternoon (early morning or first appointment after lunch are better bets for not having to wait).
• Don't go to the emergency room for anything that isn't an actual emergency (bleeding, broken, not conscious, can't breathe...well, you get the point).

Any other tips from readers out there?

if you want to end the war and stuff, you gotta sing loud!

My housemate decided to play Alice's Restaurant tonight. I haven't listened to it in ages but all the words came flooding back, filling me with nostalgia for that summer afternoon when I first heard it.

I was 12 and my life was never quite the same afterwards.

My brother was outside, washing his VW GTI. He was 17, my idol. I wanted to be just like him when I grew up. He had his JVC boombox outside with him. Playing at the loudest possible volume was Alice's Restaurant.

I had never heard of such a song, a song that was essentially a story. It was a completely revolutionary concept to me. I wandered outside to ask him who this was, this avant garde story teller.

He rewound the tape and started it over again. "Arlo Guthrie," was all he said. We both sat on the concrete of the driveway for twenty minutes while the song played, laughing at the funny parts.

"Yes, sir, Officer Obie. I cannot tell a lie. I put that envelope under that garbage."

"Obie, I don't think I can pick up the garbage with these handcuffs on."

"Kid, we don't want any hangings." And I said, "Obie, did you think I was gonna hang myself for littering?"

And the meanest, ugliest, nastiest one, the meanest father-raper of 'em all, was coming over to me and he was mean n' ugly n' nasty n' horrible and all kinds a things and he sat down next to me and said, "Kid, whaddya get?" And I said, "I didn't get nothin'. I had to pay fifty dollars and pick up the garbage." He said, "What was you arrested for, kid?" And I said, "Littering."

"I mean, I mean, I mean, I'm sittin' here on the bench, I'm sittin' here on the group W bench 'cause you wanna know if I'm moral enough to join the army, burn women/kids/houses n' villages after bein' a litterbug." He looked at me and said, "Kid, we don't like your kind."

The intangible thing about this song, the genius of this song, is the subtle, radical nature of the story. It's a simple enough story about a guy who was, fortuitously as it turns out, arrested for littering. That turns out to be the reason he was rejected from the draft. The messages are clearly relevant to the 60's anti-war movement, but if you listen carefully, they are still applicable today.

"If you wanna end the war and stuff, you gotta sing loud."

I think the seeds of my liberal activism were already planted, maybe they had always been there, but they certainly blossomed a little that afternoon in the driveway.

I didn't grow up to be exactly like my brother, but we are very close. He's been pretty sad lately, which makes me sad for him. We were IMing tonight and I randomly typed some of the above lyrics. He immediately got the reference. It made him smile.

cura te ipsum or primum non nocere?

I didn't enter the medical profession to make money. I entered medicine, pediatrics specifically, because I had that semi-altruistic desire to help people. I say semi-altruistic because some would argue that true altruism does not exist, that there is always something in it for you, even if it's just feeling good about helping someone.

But that's a philosophical debate for another day.

I read an article this morning in the NY Times that troubled me on many levels. Doctors in Shymkent, Kazakhstan being sued for giving unnecessary blood transfusions because they profited from it. They claim that their salaries are so low that it forces them to make money where they can, $10 per transfusion as it turns out.

Ok. While the ethical quandaries abound, some might argue that if they're not hurting anyone, then what's the problem, right?

Wrong.

Some of the children who received these unnecessary blood transfusions now have HIV.

Primum non nocere, in this case, trumps cura te ipsum. $10? Seriously?

updates

It's been an interesting week in health care. Just a few highlights, in no particular order, in case you were paying more attention to the Alberto Gonzales shenanigans.

• Low-acid coffee, like low-acid OJ, is now being marketed for people who have bad reflux. Not that there's really any evidence to support this. An excerpt from the NY Times article by Andrew Martin :
  

  A recent study by Stanford University researchers found that there was little scientific evidence to support the idea that eliminating coffee — and several other foods and drinks — helps cure persistent heartburn.

  “It’s as much mythology as anything,” said Dr. Joel E. Richter, chief of medicine at Temple University’s School of Medicine in Philadelphia and past president of the American College of Gastroenterology. “The evidence that coffee is injurious to the stomach isn’t there.”

  The Stanford study, that appeared in May in The Archives of Internal Medicine, evaluated published medical reports from 1975 to 2004 on heartburn.

  The study found that there was no evidence that giving up tobacco, alcohol, coffee, spicy foods, citrus or chocolate helped decrease heartburn, known to professionals as gastroesophageal reflux disease, or GERD.

  Research on coffee’s impact on the digestive system was contradictory, the Stanford study found. “Given the conflicting reported data, the relationship between caffeine and coffee and GERD remains unclear,” the study concluded. “There is insufficient evidence to support the routine recommendation that patients with GERD avoid such behavior.”

  Dr. Lauren B. Gerson, one of the study’s authors and the director of the Esophageal and Small Bowel Disorder Center at Stanford University, acknowledges that when patients complain that coffee irritates their stomachs, she tells them to stay away from it.

  But she questions the wisdom of routinely telling patients with acid reflux to stop eating certain foods, even though such advice is still offered by the National Institutes of Health and the American Gastroenterological Association.

  All I know is that when I eat garlic or tomato, I regret it. Luckily, coffee is not an issue for me. I don't know what I would do if it was. Isn't it funny how anecdote trumps evidence in an individual, if not a population?

• Antidepressants don't help kleptomaniacs. Well, if you read the lay media coverage, that's the impression they give. However, if you read the fine print, the study published in the Journal of Clinical Psychiatry was a very small trial of Lexapro (escitalopram) vs placebo in 15 people diagnosed with kleptomania. No significant difference was found between the drug and placebo. Interestingly, this study was funded by the manufacturer of Lexapro. In case you wonder why any of this matters, there are an estimated 1.2 million kleptomaniacs in the U.S. alone.
  

• The FDA is putting new warnings on sleeping pills (Ambien, Lunesta), confirming what many people chalked up to urban myth. From the NY Times article by Stephanie Saul:

  The review was prompted, in part, by queries to the agency from The New York Times last year, after some users of the most widely prescribed drug, Ambien, started complaining online and to their doctors about unusual reactions ranging from fairly benign sleepwalking episodes to hallucinations, violent outbursts, nocturnal binge eating and — most troubling of all — driving while asleep.
  
  Night eaters said they woke up to find Tostitos and Snickers wrappers in their beds, missing food, kitchen counters overflowing with flour from baking sprees, and even lighted stoves.
  
  Sleep-drivers reported frightening episodes in which they recalled going to bed, but woke up to find they had been arrested roadside in their underwear or nightclothes. The agency said that it was not aware of any deaths caused by sleep-driving.
  
  The reports gained credence from scientific studies. A forensic toxicologist in Wisconsin, Laura J. Liddicoat, gave a presentation at a national meeting on six instances of Ambien-impaired driving.
  
  And Dr. Carlos H. Schenck and Dr. Mark W. Mahowald of the University of Minnesota said that they had been studying cases of nearly 30 Ambien users who developed unusual nighttime eating disorders.
  
  Last May in Washington, Rep. Patrick Kennedy, Democrat of Rhode Island, blamed Ambien when he crashed his car near the Capitol building.
  
  The agency also received reports of people making phone calls, purchasing items over the Internet, or having sex under the influence of sleep medication.
  
  In each case the consumers had no recollection of the events, which they said had occurred after they took their pills and headed for bed.

• Hillary Clinton and John Dingell (Dem, Michigan) introduced a bill that would expand CHIP (Children's Health Insurance Program). No matter what you think of Hillary, expanding health insurance coverage for kids is a fantastic idea.
  

  Under the bill, virtually all uninsured children would have access to coverage of some type, with or without federal subsidies. Mr. Dingell and Mrs. Clinton would give states financial incentives to cover children with family incomes up to four times the poverty level. A family of three is considered poor if its annual income is less than $17,170. Thus, the bill would allow the federal government to pay subsidies for coverage of children in a three-person family with annual income up to $68,680.

  That is higher than the limit in any state. In January, 24 states had limits at 200 percent of the poverty level, 10 had lower limits and 16 had higher ceilings. New Jersey covered children up to 350 percent of the poverty level. Gov. Eliot Spitzer of New York has proposed increasing the limit to 400 percent, from 250 percent.

  The latest budget request from President Bush would move in the opposite direction. He proposed reducing federal payments for children with family incomes above 200 percent of the poverty level, saying that would return the program to its “original objective.”

  Under the Dingell-Clinton bill, states could allow employers and parents to buy coverage through the Children’s Health Insurance Program. States could subsidize the premiums, and the federal government would help pay the cost in states that expanded their programs to cover children with family incomes up to four times the poverty level.

Not a complete round-up but at least food for thought. I didn't even mention the birth control pill ruling, as that will be a separate post when I am less irate.

more caffeine with that donut?

Caffeinated Donut Invented

Molecular biologist Robert Bohannon has created pastries with the caffeine equivalent of two cups of coffee. What do you think?

Since this is from the Onion, one immediately scoffs and says, it can't be true. However, why not? They put caffeine in so many other things, why not donuts? It would just defeat the purpose of drinking coffee with your donut. But who does that anyway?